مطالعه ای که به این منظور طراحی شده بود تا به دانشمندان در درک رشد غیرعادی مغز کودکان پیشرس به دنیا آمده کمک کند به گونه ای غیر منتظره نقش تحول در مغز انسان را کشف کرد.

دانشمندان دانشکده پزشکی دانشگاه واشینگتن در سنت لویی دریافتند مناطقی از مغز انسان که در دوران نوزادی و کودکی دارای بیشترین رشد است تقریبا به عینه شبیه مناطقی از مغز انسان است که بیشترین تغییرها را در مقایسه میان مغز انسان با مغز میمون های انسان نما و میمون ها دارد.

پژوهشگران این یافته را به همراه جزییات مقایسه مغر نوزادان به موعد متولد شده و جوانان سالم در شماره آنلاین "پروسیدینگز اف دی نشنال اکادمی اف ساینسز" منتشر ساختند.

دانشمندان این مطالعه را با این هدف انجام دادند که تاثیرهای درازمدت تولد پیش از موعد را بر رشد مغز بررسی نمایند.  این تاثیرها می تواند شامل خطر ناتوانی در یادگیری، کاستی توجه، مشکل های رفتاری و اختلال های شناختی باشد.

دکتر تری ایندر، استاد طب کودکان می گوید: "تولد های پیشرس در سال های اخیر در حال افزایش بوده، و اکنون 12 درصد از تمام نوزادان در ایالات متحده پیشرس به دنیا می آیند."  به گفته وی: "تا پیش از این، ما  در قابلیت مطالعه تاثیر تولد پیشرس بر رشد مغز محدودیت های زیادی داشتیم، زیرا داده های بسیار اندکی از آن داشتیم که رشد معمولی مغز چیست."

در میان پرسش هایی که ایندر و همکارانش امیدوار هستند به آنها پاسخ دهند این است که تا چه میزان مغز می تواند خود را با محدودیت ها و یا عقب ماندگی های ناشی از تولد پیشرس تطبیق دهد.  آنها همچنین امیدوارند بتوانند راهبردهایی برای پیشبرد چنین تطابق هایی و رشد معمولی تعیین کنند.

... [گروه پژوهشی] دریافت که قشر مخ، ناحیه چین و چروکی سطح مغز که عهده دار عملکردهای برتر ذهنی است، به صورت نامساوی رشد می کند.  با بلوغ مغز همه ناحیه های آن گسترش می یابد، اما در طول زمان رشد عادی، یک-چهارم تا یک-سوم قشر مخ تقریبا تا دو برابر دیگر نواحی قشر مخ گسترش دارد.

ون اسن [یکی از اعضای تیم پژوهش] می گوید: "آزمایشگاه من از طریق مقایسه میان انسان و میمون های ماکایو نشان داد که بسیاری از این ناحیه های دارای رشد بالا در انسان ها نتیجه تغییرات تکاملی اخیری است که مغز انسان را از مغز هر نخستینی بسیار بزرگتر ساخت." وی می افزاید: "این رابطه کامل نیست، اما خیلی مهم تر از آنست که آنرا نتیجه شانس بدانیم." ...

Baby Brain Growth Mirrors Changes from Apes to Humans Data to help assess adverse effects of premature birth EurekAlert! Jul-12-2010 Contact: Michael C. Purdy purdym@wustl.edu 314-286-0122 Washington University School of Medicine
A study undertaken to help scientists concerned with abnormal brain development in premature babies has serendipitously revealed evolution's imprint on the human brain.	Areas of expansion in the human cortex during infancy and childhood, top, closely match areas of change in the human brain when compared to the brains of apes and monkeys. Yellow areas expanded the most, followed by orange, red, blue and light blue areas. Credit: Washington University School of Medicine in St. Louis.

Researchers report the finding in a detailed comparison of the brains of normal-term infants and healthy young adults published online in the Proceedings of the National Academy of Sciences.

Scientists conducted the study to help assess the long-term effects of premature birth on brain development. These can include increased risks of learning disabilities, attention deficits, behavioral problems and cognitive impairments.

"Pre-term births have been rising in recent years, and now 12 percent of all babies in the United States are born prematurely," says Terrie Inder, MD, PhD, professor of pediatrics. "Until now, though, we were very limited in our ability to study how premature birth affects brain development because we had so little data on what normal brain development looks like."

Among the questions Inder and her colleagues hope to answer is the extent to which the brain can adapt to developmental limitations or setbacks imposed by early birth. They are also helping to develop clinical strategies to promote such adaptations and normalize development.

The study used a technique for comparative brain anatomy called surface reconstruction pioneered by senior author David Van Essen, PhD, Edison Professor and head of the Department of Anatomy and Neurobiology. Surface reconstruction helps scientists more closely align comparable regions and structures in many different brains and has been used to create online atlases of brain structure.

First author Jason Hill, an MD/PhD student, analyzed the brain scans of 12 full-term infants and compared these to scans from 12 healthy young adults. Data from the two groups were combined into a single atlas to help scientists quantify the differences between the infant and young-adult brains.

They found that the cerebral cortex, the wrinkled area on the surface of the brain responsible for higher mental functions, grows in an uneven fashion. Every region expands as the brain matures, but one-quarter to one-third of the cortex expands approximately twice as much as other cortical areas during normal development.

"Through comparisons between humans and macaque monkeys, my lab previously showed that many of these high-growth regions are expanded in humans as a result of recent evolutionary changes that made the human brain much larger than that of any other primate," says Van Essen. "The correlation isn't perfect, but it's much too good to put down to chance."

The high-growth regions are areas linked to advanced mental functions such as language, reasoning, and what Van Essen calls "the abilities that make us uniquely human." He speculates that the full physical growth of these regions may be delayed somewhat to allow them to be shaped by early life experiences.

Inder notes another potential explanation for the different development rates: the limitations on brain size imposed by the need to pass through the mother's pelvis at birth may force the brain to prioritize.

"Vision, for example, is a brain area that is important at birth so an infant can nurse and learn to recognize his or her parents," Inder says. "Other areas of the brain, less important very early in life, may be the regions that see greater growth as the child matures."

Researchers are currently conducting similar scans of premature babies at birth and years later.

"This study and the data that we're gathering now could provide us with very powerful tools for understanding what goes wrong structurally in a wide range of childhood disorders, from the aftereffects of premature birth to conditions like autism, attention-deficit disorder or reading disabilities," Inder says.

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Hill J, Inder T, Neil J, Dierker D, Harwell J, Van Essen D. Similar patterns of cortical expansion during human development and evolution. Proceedings of the National Academy of Sciences, early online edition.